Cic edizioni internazionali
Il Giornale di Chirurgia

Follow-up of multicentric HCC according to the mRECIST criteria: role of 320-Row CT with semi-automatic 3D analysis software for evaluating the response to systemic therapy

Original Article, 206 - 210
doi: 10.11138/gchir/2016.37.5.206
Tag this article
Abstract
Enhanced HTML Full text PDF
Aim. To evaluate the role of 320-detector row computed tomography (MDCT) with 3D analysis software in follow up of patients affected by multicentric hepatocellular carcinoma (HCC) treated with systemic therapy by using modified response evaluation criteria in solid tumors (mRECIST).
Patients and methods. 38 patients affected by multicentric HCC underwent MDCT. All exams were performed before and after iodinate contrast material intravenous injection by using a 320-detection row CT device. CT images were analyzed by two radiologists using multi-planar reconstructions (MPR) in order to assess the response to systemic therapy according to mRECIST criteria: complete response (CR), partial response (PR), progressive disease (PD), stable disease (SD). 30 days later, the same two radiologists evaluated target lesion response to systemic therapy according to mRECIST criteria by using 3D analysis software. The difference between the two systems in assessing HCC response to therapy was assessed by the analysis of the variance (Anova Test). Interobserver agreement between the two radiologists by using MPR images and 3D analysis software was calculated by using Cohen’s Kappa test.
Results. PR occurred in 10/38 cases (26%), PD in 6/38 (16%), SD in 22/38 (58%). Anova Test showed no statistically significant difference between the two systems for assessing target lesion response to therapy (p >0.05). Inter-observer agreement (k) was respectively of 0.62 for MPR images measurements and 0.86 for 3D analysis ones.
Conclusions. 3D Analysis software provides a semiautomatic system for assessing target lesion response to therapy according to mRECIST criteria in patient affected by multifocal HCC treated with systemic therapy. The reliability of 3D analysis software makes it useful in the clinical practice.

Vol. XXXVIII (No. 3) 2017 May - June

  1. A neurological disease on the face of an ancient Roman sculpture
    Baggieri G., Galieti L.
    doi: 10.11138/gchir/2017.38.3.115
  2. Autologous fat transplantation for secondary breast reconstruction: our experience
    Simonacci F., Grieco M.P., Bertozzi N., Raposio E.
    doi: 10.11138/gchir/2017.38.3.117
  3. Deep spinal infection in instrumented spinal surgery: diagnostic factors and therapy
    Dobran M., Marini A., Gladi M., Nasi D., Colasanti R., Benigni R., Mancini F., Iacoangeli M., Scerrati M.
    doi: 10.11138/gchir/2017.38.3.124
  4. Necrotizing fasciitis associated with primary cutaneous B-cell lymphoma. A case report
    Spiridakis K.G., Intzepogazoglou D.S., Flamourakis M.E., Sfakianakis E.E., Daskalaki A.V., Vakonaki E.K.., Rahmanis E., Kostakis G.E., Christodoulakis M.S.
    doi: 10.11138/gchir/2017.38.3.130
  5. Epidural abscess imitating recurrent pilonidal sinus: a case report
    Koutserimpas C., Nikitakis N., Skarpas A., Lada M., Papachristou E., Velimezis G.
    doi: 10.11138/gchir/2017.38.3.135
  6. Primitive squamous cell carcinoma of the breast (SCCB): case report of an uncommon variant of metaplastic carcinoma
    Punzo C., Fortarezza F., De Ruvo V., Minafra M., Laforgia R., Casamassima G., Pezzuto F., Punzi A., Caporusso C., Angelelli G., Palasciano N.
    doi: 10.11138/gchir/2017.38.3.139
  7. Polythelia in a 13-year old girl
    Halleland H.H., Balling E., Tei T., Arcieri S., Mertz H., Mele M.
    doi: 10.11138/gchir/2017.38.3.143
  8. Primary intestinal choriocarcinoma in a patient with long-standing Crohn’s disease
    Pezzuto F., Fortarezza F., Falcone V., Quintiliani C., Piscitelli D.
    doi: 10.11138/gchir/2017.38.3.147
  9. Medico legal aspects on neuromonitoring in thyroid surgery: informed consent on malpractice claims
    Demontis R., Pittau M.R., Maturo A., Petruzzo P., Calò G.
    doi: 10.11138/gchir/2017.38.3.149
  10. ATLAS OF ANATOMY, Latin nomenclature (3rd edition)
    Di Matteo G.
  11. III CONGRESSO NAZIONALE S.I.C.U.T. DI PRIMAVERA La Chirurgia d’Urgenza e del Trauma Italiana nei contesti di maxiemergenza
    Di Matteo G.
Last Viewed articles: la lista degli ultimi x visitati.
  1. Follow-up of multicentric HCC according to the mRECIST criteria: role of 320-Row CT with semi-automatic 3D analysis software for evaluating the response to systemic therapy
    Telegrafo M., Dilorenzo G., Di Giovanni G., Cornacchia I., Stabile Ianora A.A., Cornacchia I., Stabile Ianora A.A., Angelelli G., Moschetta M.
    doi: 10.11138/gchir/2016.37.5.206
credits