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Unusual case of multilocular cystic renal cell carcinoma treated with nephron-sparing technique

Casistica clinica, 345 - 348
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Summary: Unusual case of multilocular cystic renal cell carcinoma treated with nephron-sparing technique
V.G. Papadimitriou, D. Takos, V. Adamopoulos, U. Vegertaki, J.M. Heretis, K.N. Stamatiou, F.A. Sofras
Introduction. The spectrum of cystic renal neoplasms includes both benign and malignant tumors and the order is as follows: benign multilocular cyst, multilocular cystic renal cell cancer and cystic renal cell cancer. Gross similarities among multicystic tumors of the kidney may cause conflict in the diagnosis and treatment of these lesions.
Case report. We report a 37-year-old male who presented with a mild persistent left flank pain and a painful left renal mass. After a series of examinations including abdominal ultrasound, intravenous pyelography and computed tomography, he underwent surgical exploration despite the benign appearance on radiological evaluation. A partial nephrectomy has been finally performed. The pathologic examination showed multilocular cysts lined by flattened to cuboidal epithelium, separated by cellular spindle cell stroma. Few scattered foci of lining cells showing the typical features of clear cell carcinoma of the kidney have been revealed also.
Conclusion. According to the current literature, prognosis of multilocular renal clear cell carcinoma is excellent in most of the cases. Indeed, metastases development is rare while local recurrence is related to inadequate local excision. Despite the relatively benign nature, urologist should be always aware of such complex renal masses since both the non specific clinical findings and poor contribution of imaging examinations make the preoperative distinction of benign from malignant cystic renal neoplasias difficult.

Versione italiana
Riassunto: Caso raro di nefroma multiloculare cistico con foci di carcinoma a cellule chiare trattato con tecnica nephron-sparing.
V.G. Papadimitriou, D. Takos, V. Adamopoulos, U. Vegertaki, J.M. Heretis, K.N. Stamatiou, F.A. Sofras
Il nefroma multiloculare cistico è una lesione benigna relativamente rara del rene da ascrivere al gruppo delle malatie cistiche non genetiche. Sia la presentazione clinica che l’ imaging radiologica non sono caratteristici e la diagnosi esatta si fa solo con l’esame istologico definitivo del pezzo asportato.
Presentiamo un caso di nefroma cistico multiloculare (MLCN) con foci di carcinoma a cellulle chiare. La diagnosi differenziale tra MLCN e altre malattie cistiche del rene è difficile perché la fenomenologia clinica non è specifica e l’imaging non consente una corretta diagnosi.
Anche se il MLCN è una malattia benigna, ci sono alcune rare pubblicazioni nella letteratura medica in cui si descrivono casi di carcinoma. Il nostro paziente è libero da malattia 12 anni dopo l’ intervento chirurgico di exeresi.

Vol XL (No. 4) 2019 July-August

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