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Il Giornale di Chirurgia

Chemio-radioterapia neoadiuvante nel carcinoma del retto.
Studio clinico a lungo termine in un singolo centr

Articolo, 82
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Abstract
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The standard therapy for patients with clinically resectable rectal
cancer is generally surgery. Tumor regression can be obtained by preoperative
radio-chemotherapy that allows radical tumor resection with an
increase in sphincter-saving procedures. The aim of this study was to
evaluate the safety and efficacy of preoperative combined radiotherapy
(RT) and chemotherapy (CT) in patients with T2 and T3 rectal cancer.
Between September 1999 and December 2008, 58 patients with
palpable rectal adenocarcinoma received preoperative radiotherapy by
the 3-field technique to a total of 50.5 Gy (5 x 1.8 Gy/die for a total
of 28 sessions) and chemotherapy with 5-fluorouracil by continuous intravenous
infusion. Surgery, 19 resections according to Miles (32%)
and 39 anterior resections (67%) with total mesorectal excision, was
performed 6 weeks later. Alive and free disease 33 (57%), Alive with
metastases 3 (5%) deceased 15 (26%) Loose 7 (12%). The histopathological
examination showed total tumor regression in 12 patients
(20%). Local response to preoperative RT/CT was highly satisfactory,
allowing anal sphincter preservation with a low local recurrence rate.
Optimization of the combined therapy could yield even more optimal
results.

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