Extra-gonadal choriocarcinoma is an extremely rare highly malignant neoplasm with a poor prognosis. In the gastrointestinal tract it usually arises in stomach, esophagous, bowel intestine and colon. Only few cases are pure and not associated with a classic adenocarcinoma.
The correlation of Crohn’s disease with choriocarcinoma is not reported.
We describe a case of 47-year old man with primary choriocarcinoma of the colon in a previously documented Crohn’s disease.