Situs viscerum inversus totalis is a rare defect with a genetic predisposition, which can present difficulties in the management of abdominal
pathology, especially in laparoscopic surgery (mirror-image anatomy).
We report the case of a 52-year-old female with situs viscerum inversus totalis, known from pediatric age, with a medical history of colic pain in the epigastrium radiating to the right abdominal quadrant. Laparoscopic cholecistectomy was safely performed with a three trocar technique.
To the best of our knowledge this is the first time that laparoscopic cholecistectomy by three trocars was performed in a patient with situs viscerum inversus. We also review the relevant literature concerning this issue.