VOLUME 30 - NUMBER 51 - 2009

Radioterapia intraoperatoria (IORT) nel carcinoma mammario in stadio iniziale. Risultati preliminari in 77 pazienti

  • Valduga P., Zani B., Mussari S., Eccher C.
  • Articolo Originale, 026-027
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  • Purpose: To verify feasibility and effectiveness of IORT (intraoperative radiotherapy) in patients with early stage breast cancer, especially in regard to prevention of recurrence and treatment toxicity.

    Methods: From october 2000 to november 2006 we operated on 77 patients with stage I breast cancer. We have selected these patients on the basis of a preestablished experimental IORT protocol, participing in a national research project. All these patients underwent a surgical procedure including quadrantectomy of the breast and IORT (average dose 23 Gy).

    Results: The median follow-up is 69 months (range 18-94 months). We didn’t detected local relapses in any patient. One patients developed further cancer in the other breast. Two patients developed metastasis (one dead). The wound-healing average time was 8 days. We evalueted the treatment late toxicity at 36 months in 64 patients: we detected circumscribed fibrosis (grade 2) in 19 patients; fibrosis with skin retraction (grade 3) in 2 patients; symptomless fat-necrosis in 39 patients (mammographic finding).

    Conclusions: In our experience, concerning conservative treatment of early breast cancer, IORT proved to be a feasible procedure, causing poor morbidity. However, in spite of valuable preliminary results, a longer follow-up is required to establish the impact of IORT on relapse control and final cosmetic result.

  • KEY WORDS: intraoperative radiotherapy, IORT, breast cancer.