VOLUME 30 - NUMBER 51 - 2009

Continuous leakage monitoring with Sn-medronate - 99mTc - labelled RBC and hand-held gamma-probe during hypertermic isolated limb and lung perfusion

  • Villa G., De Cian F., Pomposelli E., Santoni R., Bodrato S., Sambuceti G.
  • Articolo Originale, 240-241
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  • The aim of this study was to analyze the value of continuous leakage monitoring with red blood cells (RBC) labelled with 99mTcmedronate and an external scintillation detector (surgical probe) in patients treated with hyperthermic isolated limb perfusion (ILP) with tumor necrosis factor-alpha (TNF alpha) and melphalan. Systemic hematological and metabolic profiles and tumor response were determined. The mean isotopically measured leakage was 5.8% per hour. The correlation between the monitored systemic activity in the blood by surgical probe and by blood samplings were calculated. A good correlation was observed between the two techniques. Patients with a low leakage rate showed reduced adverse effect. Real time monitoring of the leakage during ILP obtained with this method seems to be in our experience easy, safe and accurate, and serves as a good guide for the effectiveness of isolation during perfusion.

  • KEY WORDS: 99mTc-medronate, surgical probe, isolated limb perfusion, tumor necrosis factor-alpha, melphalan, leakage.