This study indentified that the major prognostic factors related with survival of surgical resected cholangiocarcinoma were the radicality of surgery and the presence of macrovascular invasion. Moreover we identified that perihilar cholangiocarcinoma have more frequently negative clinico-pathological factors such as non radical (R+) resection, perineural infiltration and macro-vascular invasion compared to intrahepatic peripheral tumors. Moreover perihilar tumors are associated with shorter long-term survival.